How Much Does Spravato (Esketamine) Cost?
How Much Does Spravato Cost?
Understanding Pricing, Insurance, and Treatment Options
Pursuing mental health treatment can feel daunting, especially when traditional therapies like medication or talk therapy haven’t worked. At Elevium, we know that mental health is deeply personal - and treatment should be too.
That’s why we’re proud to offer Spravato (esketamine), an FDA-approved therapy for treatment-resistant depression and depressive symptoms with suicidal thoughts. This innovative treatment provides hope and rapid relief for patients who haven’t found success with conventional antidepressants.
How Much Does Spravato Cost?
The cost of Spravato therapy varies depending on several factors, including dosage, session frequency, and insurance coverage. Nationally, out-of-pocket costs for Spravato typically range from $600–$1,200 per session, depending on the prescribed dosage (56 mg or 84 mg) and the clinical monitoring required. However, Elevium offers Spravato exclusively through insurance. That means we do not accept self-pay for Spravato sessions. Your total cost depends on your individual insurance coverage, deductible, and copay requirements. Learn more about our self-pay Ketamine Therapy options for uninsured patients.
What Is Spravato?
Spravato is a nasal spray that delivers esketamine, a form of ketamine, directly through the nasal mucosa for rapid absorption. Unlike traditional antidepressants that act on serotonin or norepinephrine, esketamine works on the glutamate system, the brain’s primary excitatory neurotransmitter network.
This unique mechanism helps restore healthy neural activity, promote new synaptic connections, and rebalance mood-related brain circuits. Many patients experience a noticeable improvement in mood and thought patterns within hours or days rather than weeks. Learn more in our article: How Spravato Works
How Spravato Works at Elevium
Every Spravato session at Elevium is carefully conducted in-office under the supervision of trained medical professionals.
- Administration: Patients self-administer the nasal spray while being monitored by our clinical team.
- Observation: Each session includes about two hours of observation to ensure safety and comfort.
- Treatment cadence: Elevium follows the FDA-recommended Spravato protocol:
- Weeks 1–4 (Induction Phase): 2 sessions per week
- Weeks 5–8: 1 session per week
- Ongoing Maintenance: 1 session per week or every other week, depending on individual progress
This structured approach allows the brain to adapt and sustain long-term improvements while minimizing side effects.
Who Is Spravato For?
Spravato is FDA-approved for adults with:
- Treatment-resistant depression (TRD): Depression that hasn’t improved after trying at least two antidepressant medications.
- Major depressive disorder with suicidal thoughts or actions: Spravato can help reduce the intensity of these thoughts rapidly.
Because it is a controlled medication, Spravato must be administered under medical supervision in a certified treatment center - such as Elevium.
What Affects the Cost of Spravato?
Even with insurance, there are several considerations that can affect what you pay:
- Dosage: Your Elevium clinician will determine whether 56 mg or 84 mg is appropriate for your treatment plan.
- Frequency: Sessions are more frequent during the induction phase and taper as symptoms improve.
- Insurance policy: Each plan has its own requirements for coverage approval, copays, and prior authorization.
- Clinical oversight: Every session includes physician supervision and monitoring for safety, which is required by the FDA.
Our team helps you navigate these details and communicates directly with your insurance provider to confirm coverage before starting treatment.
Insurance Coverage and Assistance
Because Elevium’s Spravato program is insurance-based, we work directly with your provider to minimize your expenses. Coverage typically includes both the medication and clinical supervision fees, though copays or deductibles may apply depending on your plan.
If your insurance does not cover Spravato, our team can guide you toward:
- Patient assistance programs that may reduce medication costs, or
- Alternative therapies, such as Ketamine Therapy, which can provide similar benefits via a self-pay model.
What to Expect During Treatment
Many patients experience mild dissociation, drowsiness, or dizziness during their session, which typically resolves within a couple of hours. Our staff remains present throughout your visit to ensure your comfort and safety. Because Spravato can cause temporary sedation, you’ll need a trusted friend, family member, or ride service to take you home afterward. Read more: What to expect during Spravato

Which Treatment Is Right For Me?
Not sure where to begin? Take a short quiz and we’ll guide you to the right treatment.
Taking the Next Step
Spravato has helped many of our patients reclaim their energy, motivation, and sense of self when traditional treatments fell short. If you’re curious about whether Spravato® might be right for you:
- Schedule a consultation - We’ll assess your history and determine if Spravato® fits your treatment goals.
- Check your insurance - Our staff can help confirm eligibility and expected coverage.
- Explore alternatives - If insurance isn’t an option, ask about Ketamine Therapy as a flexible, self-pay alternative.
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